Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin.

Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin.

APOL1, a secreted high-density lipoprotein, is expressed in different human tissues. Genetic variants of APOL1 are described to be associated with the development of end stage renal diseases in African Americans. In human kidney, APOL1 is mainly expressed in podocytes that are responsible for proper...

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Bibliographic Details
Main Authors: Ahmed M Kotb, Ole Simon, Antje Blumenthal, Silke Vogelgesang, Frank Dombrowski, Kerstin Amann, Uwe Zimmermann, Karlhans Endlich, Nicole Endlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4854397?pdf=render

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http://europepmc.org/articles/PMC4854397?pdf=render

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