Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells

Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells

Abstract Background Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson’s disease (PD) and identified as vital objective for therapeutic intercession. This study investigated the neuro-protective effects of the demethoxycurcumi...

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Main Authors: Muthu Ramkumar, Srinivasagam Rajasankar, Veerappan Venkatesh Gobi, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ameer Kalandar, Ranganathan Chidambaram
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Demethoxycurcumin
Rotenone
Oxidative stress
Apoptosis
Neurodegenerative diseases
Online Access:http://link.springer.com/article/10.1186/s12906-017-1720-5

Internet

http://link.springer.com/article/10.1186/s12906-017-1720-5

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