Using Precisely Defined in vivo Microbiotas to Understand Microbial Regulation of IgE

Using Precisely Defined in vivo Microbiotas to Understand Microbial Regulation of IgE

Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum IgE levels. An increase in microbial richness, providing it occurs in a critical developmental window early in life, leads to in...

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Bibliographic Details
Main Authors: Madeleine Wyss, Kirsty Brown, Carolyn A. Thomson, Mia Koegler, Fernanda Terra, Vina Fan, Francesca Ronchi, Dominique Bihan, Ian Lewis, Markus B. Geuking, Kathy D. McCoy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
microbiota
IgE
Tregs
SCFA
gnotobiotic
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03107/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03107/full

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