Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

Abstract Background Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. The elevated activity of transcription of oncogenes is presumably to drive aspects of tumors. We hypothesized that inhibi...

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Bibliographic Details
Main Authors: Jing Zhang, Shenglan Liu, Qianyun Ye, Jingxuan Pan
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Molecular Cancer
Subjects:
Uveal melanoma
SNS-032
Transcription
Apoptosis
Cancer stem-like cells
Self-renewal
Online Access:http://link.springer.com/article/10.1186/s12943-019-1070-7

Internet

http://link.springer.com/article/10.1186/s12943-019-1070-7

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