Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms

Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms

Abstract Background Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi-1 (GSTP1) polymorphisms are related to chemotherapy-related adverse...

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Bibliographic Details
Main Authors: Xunwei Deng, Jingyuan Hou, Qiaoting Deng, Zhixiong Zhong
Format: Article
Language:English
Published: BMC 2020-12-01
Series:World Journal of Surgical Oncology
Subjects:
DPYD
GSTP1
Gene polymorphism
Chemotherapy toxicity
Hakka population
Online Access:https://doi.org/10.1186/s12957-020-02103-3

Internet

https://doi.org/10.1186/s12957-020-02103-3

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