Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross mouse strains

Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross mouse strains

A central challenge in pharmaceutical research is to investigate genetic variation in response to drugs. The Collaborative Cross (CC) mouse reference population is a promising model for pharmacogenomic studies because of its large amount of genetic variation, genetic reproducibility, and dense recom...

Full description

Bibliographic Details
Main Authors: Aharon Nachshon, Hanifa J. Abu-Toamih Atamni, Yael Steuerman, Roa’a Sheikh-Hamed, Alexandra Dorman, Richard Mott, Juliane C. Dohm, Marc Sultan, Hans Lehrach, Ron Shamir, Sascha Sauer, Heinz Himmelbauer, Fuad A. Iraqi, Irit Gat-Viks
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Genetics
Subjects:
Genetic Variation
hepatic drug disposition
Splicing isoforms
Collaborative Cross strains
eQTLs analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00172/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00172/full

Similar Items