Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002

Currently, all available antiviral drugs against influenza virus (IV) that target the virus proteins directly, like Baloxavir acid (BXA), lead to viral resistance. Therefore, cellular mechanisms and factors essential for IV replication are promising antiviral targets. As IV strongly depends on the v...

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Bibliographic Details
Main Authors: Hazem Hamza, Mahmoud M. Shehata, Ahmed Mostafa, Stephan Pleschka, Oliver Planz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
influenza virus
antivirals
combination treatment
MEK inhibitors
antiviral resistance
Baloxavir Marboxil
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.611958/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.611958/full

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