Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed

Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed

Abstract Background The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with various disorders such neuropathic pain and neuronal death following h...

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Bibliographic Details
Main Authors: Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño, Esperanza Recio-Pinto
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Neuroscience
Subjects:
NMDA
Conantokin-G
Hippocampal neurons
GluN2B
GluN2A
Online Access:http://link.springer.com/article/10.1186/s12868-017-0361-4

Internet

http://link.springer.com/article/10.1186/s12868-017-0361-4

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