Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Abstract Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestation...

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Bibliographic Details
Main Authors: Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu, Qian Yu, Zhenglai Ma, Ying Lian, Boon Seng Soh, Qingfeng Chen, Ping Liu, Yaoyong Chen, Xiaofang Sun, Rong Li, Xiumei Zhen, Yang Yu, Xiaoping Li, Yong Fan
Format: Article
Language:English
Published: SpringerOpen 2018-01-01
Series:Protein & Cell
Subjects:
mitochondria
iPSCs
TALEN
MELAS
Online Access:http://link.springer.com/article/10.1007/s13238-017-0499-y

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http://link.springer.com/article/10.1007/s13238-017-0499-y

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