Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy

Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy

Each year, millions of African children receive praziquantel (PZQ) by mass drug administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body weight, a direct extrapolation from studies of adults. A higher dose of 60 mg/kg is also acceptable for refractory cases. We con...

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Bibliographic Details
Main Authors: Amaya L. Bustinduy, David Waterhouse, Jose C. de Sousa-Figueiredo, Stephen A. Roberts, Aaron Atuhaire, Govert J. Van Dam, Paul L. A. M. Corstjens, Janet T. Scott, Michelle C. Stanton, Narcis B. Kabatereine, Stephen Ward, William W. Hope, J. Russell Stothard
Format: Article
Language:English
Published: American Society for Microbiology 2016-08-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/4/e00227-16

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http://mbio.asm.org/cgi/content/full/7/4/e00227-16

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