Modeling the impact of drug interactions on therapeutic selectivity

Modeling the impact of drug interactions on therapeutic selectivity

While drugs can interact in both target and off-target cell types, more favorable interaction in the target cell may nevertheless allow for a therapeutic window. Here, the authors show, using two yeast species as a model, that differential drug interactions indeed adjust the selective window.

Bibliographic Details
Main Authors: Zohar B. Weinstein, Nurdan Kuru, Szilvia Kiriakov, Adam C. Palmer, Ahmad S. Khalil, Paul A. Clemons, Muhammad H. Zaman, Frederick P. Roth, Murat Cokol
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05954-3
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spelling doaj-469370dc8ba0481e8780ba4f7a1c399a2021-05-11T09:52:59ZengNature Publishing GroupNature Communications2041-17232018-08-01911910.1038/s41467-018-05954-3Modeling the impact of drug interactions on therapeutic selectivityZohar B. Weinstein0Nurdan Kuru1Szilvia Kiriakov2Adam C. Palmer3Ahmad S. Khalil4Paul A. Clemons5Muhammad H. Zaman6Frederick P. Roth7Murat Cokol8Department of Pharmacology and Experimental Therapeutics, Boston University School of MedicineFaculty of Engineering and Natural Sciences, Sabanci UniversityProgram in Molecular Biology, Cell Biology & Biochemistry, Boston UniversityLaboratory of Systems Pharmacology, Harvard Medical SchoolBiological Design Center, Boston UniversityChemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MITDepartment of Biomedical Engineering, Boston UniversityDonnelly Centre and Departments of Molecular Genetics and Computer Science, University of TorontoFaculty of Engineering and Natural Sciences, Sabanci UniversityWhile drugs can interact in both target and off-target cell types, more favorable interaction in the target cell may nevertheless allow for a therapeutic window. Here, the authors show, using two yeast species as a model, that differential drug interactions indeed adjust the selective window.https://doi.org/10.1038/s41467-018-05954-3
collection DOAJ
language English
format Article
sources DOAJ
author Zohar B. Weinstein
Nurdan Kuru
Szilvia Kiriakov
Adam C. Palmer
Ahmad S. Khalil
Paul A. Clemons
Muhammad H. Zaman
Frederick P. Roth
Murat Cokol
spellingShingle Zohar B. Weinstein
Nurdan Kuru
Szilvia Kiriakov
Adam C. Palmer
Ahmad S. Khalil
Paul A. Clemons
Muhammad H. Zaman
Frederick P. Roth
Murat Cokol
Modeling the impact of drug interactions on therapeutic selectivity
Nature Communications
author_facet Zohar B. Weinstein
Nurdan Kuru
Szilvia Kiriakov
Adam C. Palmer
Ahmad S. Khalil
Paul A. Clemons
Muhammad H. Zaman
Frederick P. Roth
Murat Cokol
author_sort Zohar B. Weinstein
title Modeling the impact of drug interactions on therapeutic selectivity
title_short Modeling the impact of drug interactions on therapeutic selectivity
title_full Modeling the impact of drug interactions on therapeutic selectivity
title_fullStr Modeling the impact of drug interactions on therapeutic selectivity
title_full_unstemmed Modeling the impact of drug interactions on therapeutic selectivity
title_sort modeling the impact of drug interactions on therapeutic selectivity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description While drugs can interact in both target and off-target cell types, more favorable interaction in the target cell may nevertheless allow for a therapeutic window. Here, the authors show, using two yeast species as a model, that differential drug interactions indeed adjust the selective window.
url https://doi.org/10.1038/s41467-018-05954-3
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AT muhammadhzaman modelingtheimpactofdruginteractionsontherapeuticselectivity
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