Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a “high inflammatory/immune biotype.” Recent studies implicate both complemen...

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Bibliographic Details
Main Authors: Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02002/full