Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions

Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions

BackgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that oxygen depletion accounts for the FLASH spari...

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Bibliographic Details
Main Authors: Gabriel Adrian, Elise Konradsson, Sarah Beyer, Anders Wittrup, Karl T. Butterworth, Stephen J. McMahon, Mihaela Ghita, Kristoffer Petersson, Crister Ceberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
FLASH
ultra-high dose rate irradiation
clonogenic assay
normoxia
radiotherapy
radiobiology
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.686142/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.686142/full

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