Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Summary: Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their secretion remain obscure. We report on a genome-wide CRISPR-Cas9 screen for genes affecting trafficking of polymerogenic α1ATH334D. A CRISPR en...

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Bibliographic Details
Main Authors: Adriana Ordóñez, Heather P. Harding, Stefan J. Marciniak, David Ron
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
α1-antitrypsin
SURF4
LMAN1
ERGIC-53
cargo receptors
polymer trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004836

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721004836

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