Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway

Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway

As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2 system to affect the pathological process of liver injury in T2DM. Ellagic acid (EA) is versatile for protecting oxidative stress damage and metabolic disorders. In the present study, we investigated the effect...

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Bibliographic Details
Main Authors: Xiaoqin Ding, Tunyu Jian, Yuexian Wu, Yuanyuan Zuo, Jiawei Li, Han Lv, Li Ma, Bingru Ren, Lei Zhao, Weilin Li, Jian Chen
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Type 2 diabetes mellitus
Ellagic acid
Oxidative stress
Insulin resistance
miR-223
keap1-Nrf2 system
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218349023

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http://www.sciencedirect.com/science/article/pii/S0753332218349023

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