Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to...

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Bibliographic Details
Main Authors: Nicolas S. Merle, Juliette Leon, Victoria Poillerat, Anne Grunenwald, Idris Boudhabhay, Samantha Knockaert, Tania Robe-Rybkine, Carine Torset, Matthew C. Pickering, Sophie Chauvet, Veronique Fremeaux-Bacchi, Lubka T. Roumenina
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
complement – immunological term
complement factor H
hemolysis
kidney
acute tubular damage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01772/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01772/full

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