NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

<p>Abstract</p> <p>Background</p> <p>The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and promotes tumor cell survival after radiation-induced DNA damage. Because the pathway may not be completely inhibited after blockade of PI3K itself,...

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Bibliographic Details
Main Authors: Fokas Emmanouil, Yoshimura Michio, Prevo Remko, Higgins Geoff, Hackl Wolfgang, Maira Sauveur-Michel, Bernhard Eric J, McKenna W Gillies, Muschel Ruth J
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Radiation Oncology
Subjects:
PI3K
mTOR
Radiosensitization
Endothelial cells
VEGF
Online Access:http://www.ro-journal.com/content/7/1/48

Internet

http://www.ro-journal.com/content/7/1/48

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