Traumatic brain injury does not disrupt costimulatory blockade-induced immunological tolerance to glial-restricted progenitor allografts

Traumatic brain injury does not disrupt costimulatory blockade-induced immunological tolerance to glial-restricted progenitor allografts

Abstract Background Cell transplantation-based treatments for neurological disease are promising, yet graft rejection remains a major barrier to successful regenerative therapies. Our group and others have shown that long-lasting tolerance of transplanted stem cells can be achieved in the brain with...

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Bibliographic Details
Main Authors: Rui Wang, Chengyan Chu, Zhiliang Wei, Lin Chen, Jiadi Xu, Yajie Liang, Miroslaw Janowski, Robert D. Stevens, Piotr Walczak
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
Glial-restricted progenitors
Co-stimulation blockade
Immunological tolerance
Traumatic brain injury
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-021-02152-9

Internet

https://doi.org/10.1186/s12974-021-02152-9

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