Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation

Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation

Naïve CD4+ T cell differentiate into effector and regulatory subsets of helper T (Th) cells in various pathophysiological conditions and modulate tissue inflammation in autoimmune diseases. While cytokines play a key role in determining the fate of Th cells differentiation, metabolites, and metaboli...

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Bibliographic Details
Main Authors: Suyasha Roy, Zaigham Abbas Rizvi, Amit Awasthi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
T cell
cytokines
inflammation
metabolism
checkpoint
transcription factor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03036/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03036/full

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