The Diels‐Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC)

The Diels‐Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC)

Abstract Based on the Diels‐Alder reaction of vinylchromenes with electron‐poor dienophiles, we developed a strategy for the synthesis of tetrahydrocannabinol derivatives. Substituted vinyl chromenes could be converted with several dienophiles to successfully isolate several complex molecules. These...

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Bibliographic Details
Main Authors: Dr. Thomas Hurrle, Dr. Franziska Gläser, Dr. Manuel C. Bröhmer, Dr. Martin Nieger, Prof. Dr. Stefan Bräse
Format: Article
Language:English
Published: Wiley-VCH 2021-05-01
Series:ChemistryOpen
Subjects:
natural products
medicinal chemistry
fused-ring systems
cycloaddition reactions
Diels-Alder reactions
Online Access:https://doi.org/10.1002/open.202000343

Internet

https://doi.org/10.1002/open.202000343

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