Pharmaceutical Nanoparticles and the Mucin Biopolymer Barrier

Mucus in the gastrointestinal tract remains a tenacious barrier that restricts the passage of many orally administered compounds into the GIT’s epithelial layer and consequently into the systemic circulation. This results in significant decreases in the oral bioavailability of many therapeutic molec...

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Bibliographic Details
Main Authors: Ghaith Aljayyoussi, Muthanna Abdulkareem, Peter Griffiths, Mark Gumbleton
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2012-12-01
Series:BioImpacts
Subjects:
Online Access:http://dx.doi.org/10.5681/bi.2012.029