RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies

RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies

Breast cancer remains one of the most life-threatening tumors affecting women. Most patients with advanced breast cancer eventually develop metastatic diseases, which cause significant morbidity and mortality. Approximately two-thirds of patients with advanced breast cancer exhibit osteolytic-type b...

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Bibliographic Details
Main Authors: Xiaoqiu Wu, Fangfei Li, Lei Dang, Chao Liang, Aiping Lu, Ge Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RANKL
RANK
bone metastasis
breast cancer
vicious cycle
denosumab
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00076/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00076/full

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