Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line

Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line

Tertiary lymphoid structures (TLSs) associate with better prognosis in certain cancer types, but their underlying formation and immunological benefit remain to be determined. We established a mouse model of TLSs to study their contribution to antitumor immunity. Because the stroma in lymph nodes (sL...

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Bibliographic Details
Main Authors: Genyuan Zhu, Satoshi Nemoto, Adam W. Mailloux, Patricio Perez-Villarroel, Ryosuke Nakagawa, Rana Falahat, Anders E. Berglund, James J. Mulé
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
tertiary lymphoid structures
stromal cells
lymphogenesis
tumor-infiltrating lymphocytes
immune checkpoint proteins
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01609/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01609/full

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