tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far. We provide here in vitro and in vivo demonstrations that this serine protease neutralizes inhibitory chondroitin sulfate pro...

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Bibliographic Details
Main Authors: Sighild Lemarchant, Mathilde Pruvost, Marie Hébert, Maxime Gauberti, Yannick Hommet, Aurélien Briens, Eric Maubert, Yatma Gueye, François Féron, Didier Petite, Marcel Mersel, Jean-Claude do Rego, Hubert Vaudry, Jari Koistinaho, Carine Ali, Véronique Agin, Evelyne Emery, Denis Vivien
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Neurobiology of Disease
Subjects:
Type 4 disintegrin and metalloproteinase with thrombospondin motifs
Tissue plasminogen activator
Spinal cord injury
Chondroitin sulfate proteoglycans
Neurocan
Neuroplasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000473

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http://www.sciencedirect.com/science/article/pii/S0969996114000473

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