WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling

WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling

Esophageal cancer micro environment factor WNT2 was critical in cancer metastasis. However, very little is known about WNT2 receptors and their role in the malignant progression of ESCC. The clinical significance and underlying molecular mechanisms of FZD2, one of the receptors of WNT2, was further...

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Bibliographic Details
Main Authors: Yufei Fu, Qi Zheng, Yingying Mao, Xiyi Jiang, Xin Chen, Pei Liu, Bin Lv, Tuxiong Huang, Jiao Yang, Yongran Cheng, Xiaoyi Dai, Chunyan Dai, Xi Wang, Yifei Yin, Tengjiao Song, Weiyang Jin, Chang Zou, Tianhui Chen, Li Fu, Zhe Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
esophageal squamous cell carcinoma (ESCC)
metastasis
WNT2
FZD2
ubiquitination
STAT3signaling
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01168/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01168/full

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