Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming

Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming

Summary: Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell (ESC)-like state by expression of single reprogramming factor. We used CRISPR activation to perform a genome-scale, reprogramming screen in EpiSCs and identified 142 candidate genes. Our screen validate...

Full description

Bibliographic Details
Main Authors: Jian Yang, Sandeep S. Rajan, Mathias J. Friedrich, Guocheng Lan, Xiangang Zou, Hannes Ponstingl, Dimitrios A. Garyfallos, Pentao Liu, Allan Bradley, Emmanouil Metzakopian
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111930058X

Internet

http://www.sciencedirect.com/science/article/pii/S221367111930058X

Similar Items