Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
<p>Abstract</p> <p>Background</p> <p>Anti-viral CD8 T-cell activity is enhanced and prolonged by CD4 T-cell-mediated help, but negatively regulated by inhibitory B7-H1 interactions. During viral encephalomyelitis, the absence of CD4 T cells decreases CD8 T cell activity...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2012-12-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | http://www.jneuroinflammation.com/content/9/1/269 |