Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis

Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>Anti-viral CD8 T-cell activity is enhanced and prolonged by CD4 T-cell-mediated help, but negatively regulated by inhibitory B7-H1 interactions. During viral encephalomyelitis, the absence of CD4 T cells decreases CD8 T cell activity...

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Bibliographic Details
Main Authors: Phares Timothy W, Stohlman Stephen A, Hinton David R, Bergmann Cornelia C
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
Central nervous system
Encephalomyelitis
CD4<sup>+</sup> and CD8<sup>+</sup> T cells
Gliatropic coronavirus
Inflammation
Axonal damage
Online Access:http://www.jneuroinflammation.com/content/9/1/269

Internet

http://www.jneuroinflammation.com/content/9/1/269

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