Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.

BACKGROUND: Honokiol, a small-molecular weight natural product, has previously been reported to activate apoptosis and inhibit gastric tumorigenesis. Whether honokiol inhibits the angiogenesis and metastasis of gastric cancer cells remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: We tested the effec...

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Main Authors: Shing Hwa Liu, Keh Bin Wang, Keng Hsin Lan, Wen Jane Lee, Hung Chuan Pan, Sheng Mao Wu, Yen Chun Peng, Yi Ching Chen, Chin Chang Shen, Hsu Chen Cheng, Ko Kaung Liao, Meei Ling Sheu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3427156?pdf=render