A multi-scale approach to airway hyperresponsiveness: from molecule to organ

A multi-scale approach to airway hyperresponsiveness: from molecule to organ

Airway hyperresponsiveness (AHR), a characteristic of asthma that involves an excessive reduction in airway caliber, is a complex mechanism reflecting multiple processes that manifest over a large range of length and time scales. At one extreme, molecular interactions determine the force generated b...

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Bibliographic Details
Main Authors: Anne-Marie eLauzon, Jason H.T. Bates, Graham eDonovan, Merryn eTawhai, James eSneyd, Michael eSanderson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Physiology
Subjects:
Asthma
computational modeling
smooth muscle contraction
latch bridge
calcium oscillations and waves
parenchyma tethering
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00191/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00191/full

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