HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury

HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury

Objective: High-Mobility Group Box 1 (HMGB1) promotes vascular injuries induced by limb Ischemia and Reperfusion (IR), but the molecular mechanisms are not well understood. This study aimed to investigate the role of Receptor for Advanced-Glycation End products (RAGE) in HMGB1-regulated inflammatory...

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Bibliographic Details
Main Authors: Lei Mi, Ying Zhang, Yugang Xu, Xiao Zheng, Xia Zhang, Zhu Wang, Ming Xue, Xing Jin
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
High-mobility group box 1
Receptor for advanced glycation end products
Vascular injury
Limb ischemia and reperfusion
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219306766

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http://www.sciencedirect.com/science/article/pii/S0753332219306766

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