SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation

SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation

Human induced pluripotent stem cells (hiPSCs) generate all cell types in the body, but different lines can differ in their potential. Here, the authors determine that higher endogenous levels of SALL3 in hiPSCs lead to ectoderm differentiation bias and reduced mesoderm/endoderm due to DNMT3B mediate...

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Bibliographic Details
Main Authors: Takuya Kuroda, Satoshi Yasuda, Shiori Tachi, Satoko Matsuyama, Shinji Kusakawa, Keiko Tano, Takumi Miura, Akifumi Matsuyama, Yoji Sato
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09511-4

Internet

https://doi.org/10.1038/s41467-019-09511-4

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