N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation

N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation

A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which act as effective urease inhibitors with very low cytotoxicity. On...

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Bibliographic Details
Main Authors: Wei-Yi Li, Wei-Wei Ni, Ya-Xi Ye, Hai-Lian Fang, Xing-Ming Pan, Jie-Ling He, Tian-Li Zhou, Juan Yi, Shan-Shan Liu, Mi Zhou, Zhu-Ping Xiao, Hai-Liang Zhu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
urease inhibitor
n-monoarylacetothiourea
helicobacter pylori
spr
molecular dynamics
Online Access:http://dx.doi.org/10.1080/14756366.2019.1706503

Internet

http://dx.doi.org/10.1080/14756366.2019.1706503

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