An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells

An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed mathematical modelling of gene regulatory networks i...

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Bibliographic Details
Main Authors: James Davies, Andres F. Vallejo, Sofia Sirvent, Gemma Porter, Kalum Clayton, Yamkela Qumbelo, Patrick Stumpf, Jonathan West, Clive M. Gray, Nyaradzo T. L. Chigorimbo-Murefu, Ben MacArthur, Marta E. Polak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Langerhans cells
single cell transcriptomics
gene regulatory network
mathematical modelling
adaptive immunity
immunotolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.665312/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.665312/full

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