Tight nuclear tethering of cGAS is essential for preventing autoreactivity

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated. A widely accepted explanation for this is the sequestration of cGAS in the cyt...

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Bibliographic Details
Main Authors: Hannah E Volkman, Stephanie Cambier, Elizabeth E Gray, Daniel B Stetson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
nucleic acid detection
innate Immunity
antiviral immunity
cGAS
Online Access:https://elifesciences.org/articles/47491

Internet

https://elifesciences.org/articles/47491

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