Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment

Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment

Excessive exposure to manganese (Mn) can cause cognitive impairment, a common feature of Alzheimer's disease (AD), but the mechanisms remain unclear. Amyloid precursor protein (APP) is key to AD pathogenesis, and whether APP and its secretase processing are involved in Mn-induced cognitive impa...

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Bibliographic Details
Main Authors: Yiping Yang, Jie Zhang, Xiaobo Yang, Zhiying Li, Jian Wang, Cailing Lu, Aruo Nan, Yunfeng Zou
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Mn
APP
α-secretase
β-secretase
Cognitive impairment
Synaptic deficit
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321004772

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http://www.sciencedirect.com/science/article/pii/S0147651321004772

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