A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules

A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules

Major histocompatibility complex-I (MHC-I) molecules play a central role in the immune response to viruses and cancers. They present peptides on the surface of affected cells, for recognition by cytotoxic T cells. Determining which peptides are presented, and in what proportion, has profound implica...

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Bibliographic Details
Main Authors: Denise S. M. Boulanger, Ruth C. Eccleston, Andrew Phillips, Peter V. Coveney, Tim Elliott, Neil Dalchau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
antigen presentation
major histocompatibility class I
mechanistic model
interferon-γ
peptide competition
abundance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01538/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01538/full

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