Computational Study on DNA Repair: The Roles of Electrostatic Interactions Between Uracil-DNA Glycosylase (UDG) and DNA

Computational Study on DNA Repair: The Roles of Electrostatic Interactions Between Uracil-DNA Glycosylase (UDG) and DNA

Uracil-DNA glycosylase (UDG) is one of the most important base excision repair (BER) enzymes involved in the repair of uracil-induced DNA lesion by removing uracil from the damaged DNA. Uracil in DNA may occur due to cytosine deamination or deoxy uridine monophosphate (dUMP) residue misincorporation...

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Bibliographic Details
Main Authors: Yixin Xie, Chitra B. Karki, Jiawei Chen, Dongfang Liu, Lin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
uracil-DNA glycosylase
UDG enzyme
DNA damage
DNA repair
base excision repair
folding energy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.718587/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.718587/full

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