Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake[S]

The LDL receptor (LDLR) supports efficient uptake of both LDL and VLDL remnants by binding lipoprotein at the cell surface, internalizing lipoprotein through coated pits, and releasing lipoprotein in endocytic compartments before returning to the surface for further rounds of uptake. While many aspe...

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Bibliographic Details
Main Authors: Shanica Pompey, Zhenze Zhao, Kate Luby-Phelps, Peter Michaely
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520419388