The activity of SN33638, an inhibitor of AKR1C3, on testosterone and 17β-estradiol production and function in castration-resistant prostate cancer and ER-positive breast cancer

The activity of SN33638, an inhibitor of AKR1C3, on testosterone and 17β-estradiol production and function in castration-resistant prostate cancer and ER-positive breast cancer

AKR1C3 is a novel therapeutic target in castration-resistant prostate cancer (CRPC) and ER-positive breast cancer because of its ability to produce testosterone and 17β-estradiol intratumorally, thus promoting nuclear receptor signaling and tumor progression. A panel of CRPC, ER-positive breast canc...

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Bibliographic Details
Main Authors: Yarong Diana eYin, Melissa eFu, Darby G. Brooke, Daniel M. Heinrich, William A. Denny, Stephen M. F. Jamieson
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Oncology
Subjects:
Prostate-Specific Antigen
Testosterone
castration-resistant prostate cancer
17β-estradiol
AKR1C3
SN33638
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00159/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00159/full

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