Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma.

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma.

Most B cell lymphomas originate from B cells that have germinal center (GC) experience and bear chromosome translocations and numerous point mutations. GC B cells remodel their immunoglobulin (Ig) genes by somatic hypermutation (SHM) and class switch recombination (CSR) in their Ig genes. Activation...

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Bibliographic Details
Main Authors: Pilar Delgado, Ángel F Álvarez-Prado, Ester Marina-Zárate, Isora V Sernandez, Sonia M Mur, Jorge de la Barrera, Fátima Sanchez-Cabo, Marta Cañamero, Antonio de Molina, Laura Belver, Virginia G de Yébenes, Almudena R Ramiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008960

Internet

https://doi.org/10.1371/journal.pgen.1008960

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