Dysfunction of Cellular Proteostasis in Parkinson’s Disease

Despite decades of research, current therapeutic interventions for Parkinson’s disease (PD) are insufficient as they fail to modify disease progression by ameliorating the underlying pathology. Cellular proteostasis (protein homeostasis) is an essential factor in maintaining a persistent environment...

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Bibliographic Details
Main Authors: Šárka Lehtonen, Tuuli-Maria Sonninen, Sara Wojciechowski, Gundars Goldsteins, Jari Koistinaho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
UPR
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00457/full