A Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Discovery on Inflammatory Bowel Diseases

A Dietary Cholesterol-Based Intestinal Inflammation Assay for Improving Drug-Discovery on Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBD) with chronic infiltration of immune cells in the gastrointestinal tract are common and largely incurable. The therapeutic targeting of IBD has been hampered by the complex causality of the disease, with environmental insults like cholesterol-enriched Western diets p...

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Bibliographic Details
Main Authors: Nuno-Valério Silva, Diogo Carregosa, Catarina Gonçalves, Otília V. Vieira, Cláudia Nunes dos Santos, António Jacinto, Carolina Lage Crespo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
inflammatory bowel disease
dietary cholesterol
drug screening and discovery
innate immunity
myeloid cells
dietary phenolic acids
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.674749/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.674749/full

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