Therapeutic Potential of a Novel α<sub>v</sub>β<sub>3</sub> Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type

Therapeutic Potential of a Novel α<sub>v</sub>β<sub>3</sub> Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type

The mesenchymal sub-type of triple negative breast cancer (MES-TNBC) has a highly aggressive behavior and worse prognosis, due to its invasive and stem-like features, that correlate with metastatic dissemination and resistance to therapies. Furthermore, MES-TNBC is characterized by the expression of...

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Bibliographic Details
Main Authors: Billy Samuel Hill, Annachiara Sarnella, Domenica Capasso, Daniela Comegna, Annarita Del Gatto, Matteo Gramanzini, Sandra Albanese, Michele Saviano, Laura Zaccaro, Antonella Zannetti
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
triple-negative breast cancer
α<sub>v</sub>β<sub>3</sub> integrin
ψRGDechi
cell migration and invasion
epithelial-mesenchymal transition
stemness
Online Access:https://www.mdpi.com/2072-6694/11/2/139

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https://www.mdpi.com/2072-6694/11/2/139

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