STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer

STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer

The interferon‐inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex‐specific STAT1 functions in colitis and colitis‐associated colorectal cancer (CRC) using mice with specific STAT1 deletion in intestinal epithelial cells (STAT1∆IEC). Male but not f...

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Bibliographic Details
Main Authors: Ilija Crnčec, Madhura Modak, Claire Gordziel, Jasmin Svinka, Irene Scharf, Stefan Moritsch, Paulina Pathria, Michaela Schlederer, Lukas Kenner, Gerald Timelthaler, Mathias Müller, Birgit Strobl, Emilio Casanova, Editha Bayer, Thomas Mohr, Johannes Stöckl, Karlheinz Friedrich, Robert Eferl
Format: Article
Language:English
Published: Wiley 2018-04-01
Series:Molecular Oncology
Subjects:
CD8+ T cells
colitis
colorectal cancer
gender
sex
STAT1
Online Access:https://doi.org/10.1002/1878-0261.12178

Internet

https://doi.org/10.1002/1878-0261.12178

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