Dengue Virus Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent NETosis-Mediated Inflammation in Mice

Dengue Virus Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent NETosis-Mediated Inflammation in Mice

Abnormal immune responses and cytokine storm are involved in the development of severe dengue, a life-threatening disease with high mortality. Dengue virus-induced neutrophil NETosis response is associated with cytokine storm; while the role of viral factors on the elicitation of excessive inflammat...

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Bibliographic Details
Main Authors: Te-Sheng Lien, Der-Shan Sun, Shih-Che Hung, Wen-Sheng Wu, Hsin-Hou Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
dengue envelope protein domain III
dengue hemorrhage fever
neutrophil
neutrophil extracellular traps
NEtosis
Nlrp3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.618577/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.618577/full

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