The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia

The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia

Abstract Cystic fibrosis (CF) patients are extremely vulnerable to Burkholderia cepacia complex (Bcc) infections. However, the underlying etiology is poorly understood. We tested the hypothesis that short palate lung and nasal epithelial clone 1 (SPLUNC1)–epithelial sodium channel (ENaC) interaction...

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Bibliographic Details
Main Authors: Saira Ahmad, Christine Seul Ki Kim, Robert Tarran
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Respiratory Research
Subjects:
CFTR
BPIFA1
pH
Cystic fibrosis
Innate defense
Online Access:http://link.springer.com/article/10.1186/s12931-020-01454-5

Internet

http://link.springer.com/article/10.1186/s12931-020-01454-5

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