Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach

Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach

Selenoproteins are essential components of antioxidant defense, redox homeostasis, and cell signaling in mammals, where selenium is found in the form of a rare amino acid, selenocysteine. Selenium, which is often limited both in food intake and cell culture media, is a strong regulator of selenoprot...

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Bibliographic Details
Main Authors: Ghania Hammad, Yona Legrain, Zahia Touat-Hamici, Stéphane Duhieu, David Cornu, Anne-Laure Bulteau, Laurent Chavatte
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Antioxidants
Subjects:
proteomics
2-Dimensional Differential in-Gel Electrophoresis (2D-DIGE)
selenium
protein abundance
selenoprotein
replicative senescence
WI-38 cells
Online Access:http://www.mdpi.com/2076-3921/7/1/19

Internet

http://www.mdpi.com/2076-3921/7/1/19

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