CpG immunostimulatory oligodeoxynucleotide 1826 as a novel nasal ODN adjuvant enhanced the protective efficacy of the periodontitis gene vaccine in a periodontitis model in SD rats

CpG immunostimulatory oligodeoxynucleotide 1826 as a novel nasal ODN adjuvant enhanced the protective efficacy of the periodontitis gene vaccine in a periodontitis model in SD rats

Abstract Background We previously demonstrated that nasal administration of periodontitis gene vaccine (pVAX1-HA2-fimA) or pVAX1-HA2-fimA plus IL-15 as adjuvant provoked protective immunity in the periodontal tissue of SD rats. This study evaluated the immune effect of pVAX1-HA2-fimA plus CpG-ODN 18...

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Bibliographic Details
Main Authors: Guohui Bai, Hang Yu, Xiaoyan Guan, Fengjiao Zeng, Xia Liu, Bin Chen, Jianguo Liu, Yuan Tian
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Oral Health
Subjects:
Periodontitis
Periodontitis gene vaccine
CpG-ODN
Alveolar bone loss
COX-2
RANKL
Online Access:https://doi.org/10.1186/s12903-021-01763-1

Internet

https://doi.org/10.1186/s12903-021-01763-1

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