Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae

Abstract Background The mammalian Major Histocompatibility Complex (MHC) is a genetic region containing highly polymorphic genes with immunological functions. MHC class I and class II genes encode antigen-presenting molecules expressed on the cell surface. The MHC class II sub-region contains genes...

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Bibliographic Details
Main Authors: Marie Klumplerova, Petra Splichalova, Jan Oppelt, Jan Futas, Aneta Kohutova, Petra Musilova, Svatava Kubickova, Roman Vodicka, Ludovic Orlando, Petr Horin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Genomics
Subjects:
Major histocompatibility complex
Family Equidae
MHC exon 2
MHC class II loci
Positive selection
Trans-species polymorphism
Online Access:http://link.springer.com/article/10.1186/s12864-020-07089-6

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http://link.springer.com/article/10.1186/s12864-020-07089-6

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