Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Poly(ADP ribose) polymerase inhibitors (PARPi) target cancer cells deficient in homology-directed repair of DNA double-strand breaks (DSBs). In preclinical models, PARPi resistance is tied to altered nucleolytic processing (resection) at the 5’ ends of a DSB. For example, loss of either 53BP1 or Rev...

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Bibliographic Details
Main Authors: Bryan A Leland, Angela C Chen, Amy Y Zhao, Robert C Wharton, Megan C King
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
DNA repair
homologous recombination
live cell imaging
Online Access:https://elifesciences.org/articles/33402

Internet

https://elifesciences.org/articles/33402

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